遵义医科大学药学院贵州省生物催化与手性药物合成重点实验室;
青蒿素是一种从菊科蒿属植物黄花蒿(Artemisia annua L.)中分离出来的倍半萜类天然产物,具有广泛的生物活性,如抗肿瘤、抗炎、抗菌、抗恶性疟原虫等。青蒿素也是重要的抗疟先导化合物,目前临床上使用的青蒿素类抗疟药物有双氢青蒿素、蒿甲醚、青蒿琥酯。近年来的研究发现,青蒿素及其衍生物对弓形虫、血吸虫、犬新孢子虫、利什曼原虫等多种病原体也具有广泛的抑制活性。主要综述近年来青蒿素及其衍生物抗虫活性研究进展,期望对新型抗寄生虫类青蒿素药物的研发有所帮助。
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基本信息:
DOI:10.13822/j.cnki.hxsj.2022008751
中图分类号:R285
引用信息:
[1]翟荣航,王合珍,王京等.青蒿素及其衍生物的抗寄生虫活性研究进展[J].化学试剂,2022,44(04):514-521.DOI:10.13822/j.cnki.hxsj.2022008751.
基金信息:
贵州省科技厅项目([2017]1219); 遵义市科技局项目(遵市科合社字(2018)27号,遵市科合支撑HZ字(2020)293号)