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2025, 02, v.47 8-15
过二硫酸盐在农药和医药中间体合成中的应用
基金项目(Foundation): 国家自然科学基金项目(22201300); 中国人民大学“123”金课建设项目及教学改革项目(JYXM202337)
邮箱(Email):
DOI: 10.13822/j.cnki.hxsj.2024.0445
摘要:

过硫酸盐是一种廉价、易于操作和环境友好的强氧化剂,广泛应用于有机合成、电子工业、土壤修复、纺织印染、造纸、矿产开采、医用消毒等领域。在加热、光照或过渡金属存在条件下,过硫酸盐可分解生成硫酸根自由基负离子(SO4),这种自由基负离子具有很强的单电子氧化性,能够氧化多种中性分子或负离子,生成相应的自由基活性中间体,后续可进行一系列化学转化,从而构建结构多样性的化合物。主要介绍过二硫酸盐在农药和医药中间体合成中的应用,包括氯虫苯甲酰胺类杀虫剂、抗精神病药物依匹哌唑、抗肿瘤药物替吡法尼、西地那非、单环β-内酰胺类抗生素、生物碱Botryllazine A以及萜类(+)-Chromazonarol等,期望能够进一步开发过硫酸盐在有机合成和制药领域的更多应用。

Abstract:

Persulfate is an economical, easy to operate, and environmentally friendly strong oxidant, which is widely used in organic synthesis, electronics industry, soil remediation, textile printing and dyeing, papermaking, mineral mining, medical disinfection, and other fields.Upon exposure to heat, light, or transition metals, persulfate can be decomposed into sulfate radical anions(SO4).These radical anions exhibited robust single electron oxidation capabilities, which can oxidize a variety of neutral molecules or anions to form the corresponding free radical active intermediates.This facilitates a multitude of chemical transformations, allowing for the construction of structurally diverse molecules.This review primarily discussed the application of persulfate in the synthesis of pesticides and pharmaceutical intermediates, including chlorantraniliprole insecticides, antipsychotic drug epipiprazole, antitumor drug tipifarnib, sildenafil, monocyclic β-lactam antibiotics, alkaloid Botryllazine A and terpene(+)-Chromazonarol, etc.It is expected to further develop more applications of persulfate in in organic synthesis and pharmaceutical fields.

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基本信息:

DOI:10.13822/j.cnki.hxsj.2024.0445

中图分类号:TQ125.14;TQ450.1;TQ460.3

引用信息:

[1]吕雷阳,高龙强,温光永等.过二硫酸盐在农药和医药中间体合成中的应用[J].化学试剂,2025,47(02):8-15.DOI:10.13822/j.cnki.hxsj.2024.0445.

基金信息:

国家自然科学基金项目(22201300); 中国人民大学“123”金课建设项目及教学改革项目(JYXM202337)

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